An innovative approach to preventing bleeds
in hemophilia B and hemophilia A with inhibitors
The clotting cascade is a series of steps, like a domino effect, where each domino represents a different clotting protein. When the dominoes fall properly, clotting occurs.
Finding balance may be a challenge for people living with hemophilia with inhibitors
Alhemo® helps keep blood in balance
Helps the body create the right amount of thrombin
Keeps thrombin levels consistent without peaks and troughs
Works fast and exits the body quickly in 4 daysa
It’s important to take Alhemo® daily, especially during the first 4 weeks, to ensure you get the correct maintenance dose and stay protected from bleeding. Always use Alhemo® exactly as prescribed. Do not stop or miss doses without first consulting your healthcare provider, as this may reduce your protection against bleeding. To find the right maintenance dose for you, your provider will check Alhemo® levels in your blood. Additional blood tests may be done during treatment.
aAfter your Day 1 loading dose, the amount of Alhemo® builds up in the body to a stable amount around Day 4, and remains stable with daily maintenance doses. If you stop Alhemo®, 90% of it is expected to leave the body by the end of approximately 4 days after the last dose. The time for 50% of drug to leave the body is approximately 1 day.
See how Alhemo® works in the body
See the science behind the balance. This video breaks down how Alhemo® works in the clotting cascade.
For hemophilia B with inhibitors:
Clotting cascade without hemophilia
- Factor 9 is part of the clotting cascade that falls onto other dominoes to form clots and prevent bleeding.
- A protein called tissue factor pathway inhibitor, or TFPI, is also part of the process. It blocks the rest of the cascade’s dominoes so there is not too much clotting.
Clotting cascade in hemophilia B with inhibitors
- In hemophilia B with inhibitors, the Factor 9 domino cannot fall onto the next domino, and TFPI still blocks the dominoes from falling on the other side of the cascade. When the dominoes do not fall, clots will not form, and bleeding may occur.
How Alhemo® works
- Alhemo® stops TFPI from blocking the dominoes, so they can continue to fall, even without Factor 9 and with inhibitors.
Bleed prevention
- As a result, the domino cascade can be completed and a clot can form.
For hemophilia A with inhibitors:
Clotting cascade without hemophilia
- Factor 8 is part of the clotting cascade that falls onto other dominoes to form clots and prevent bleeding.
- A protein called tissue factor pathway inhibitor, or TFPI, is also part of the process. It blocks part of the rest of the cascade so there is not too much clotting.
Clotting cascade in hemophilia A with inhibitors
- In hemophilia A with inhibitors, the Factor 8 domino cannot fall onto the next domino and TFPI still blocks the dominoes from falling on the other side of the cascade. When the dominoes do not fall, clots will not form, and bleeding may occur.
How Alhemo® works
- Alhemo® stops TFPI from blocking the dominoes so they can continue to fall, even without Factor 8 and with inhibitors.
Bleed prevention
- As a result, the domino cascade can be completed and a clot can form.
Proven to prevent bleeds
Learn more about how Alhemo® works to reduce bleeds.
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